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Clinical Practice Guidelines

One of the main objectives of the ISRS is to elucidate best practices and provide guidance for the safe and effective practice of radiosurgery. During the past several years, a number of important guidelines have been published under the direction of and with input from global experts.  Additional guidelines are in development.    

This Guideline development process reflects a mentorship strategy intended to develop the next generation of leaders in radiosurgery as each project lead is matched with a senior academician.  The ISRS is grateful for the considerable time and effort of each of the contributors.

Most of the following guidelines may be accessed free of charge via open access by clicking on the publication titles.

EXTRACRANIAL

SPINE

REIRRADIATION SPINE STEREOTACTIC BODY RADIATION THERAPY (SBRT) FOR SPINAL METASTASES
Myrehaug S, Sahgal A, Hayashi M, Levivier M, Ma L, Martinez R, Paddick I, Régis J, Ryu S, Slotman B, De Salles A
J Neurosurg Spine. 2017 Jul 14:1-8.
DOI: 10.3171/2017.2.SPINE16976.

STEREOTACTIC BODY RADIOTHERAPY FOR DE NOVO SPINAL METASTASES
Husain ZA, Sahgal A, De Salles A, Funaro M, Glover J, Hayashi M, Hiraoka M, Levivier M, Ma L, Martínez-Alvarez R, Paddick I, Régis J, Slotman BJ, Ryu S
J Neurosurg Spine. 2017 Jun 9:1-8.
DOI: 10.3171/2017.1.SPINE16684. 

In Development
Post-Op Spine SRS: Salman Faruqui and Antonio De Salles 

 

INTRACRANIAL

BENIGN TUMORS

STEREOTACTIC RADIOSURGERY FOR SECRETORY PITUITARY ADENOMAS
Mathieu D, Kotecha R, Sahgal A, De Salles A, Fariselli L, E. Pollock B, Levivier M, Ma L, Paddick I, Regis J, Yomo S, H. Suh J, Rubens M, P. Sheehan J.
J Neurosurg Spine. 2021 Sep 3.
DOI: 10.3171/2021.2.JNS204440.

STEREOTACTIC RADIOSURGERY FOR INTRACRANIAL NONCAVERNOUS SINUS BENIGN MENINGIOMA: INTERNATIONAL STEREOTACTIC RADIOSURGERY SOCIETY SYSTEMATIC REVIEW, META-ANALYSIS AND PRACTICE GUIDELINE
Marchetti M, Sahgal A, A F De Salles A, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan J, Suh JH, Yomo S, Fariselli L
Neurosurgery. 2020 May 28.
DOI: 10.1093/neuros/nyaa169

STEREOTACTIC RADIOSURGERY FOR NON-FUNCTIONING PITUITARY ADENOMAS: META-ANALYSIS AND INTERNATIONAL STEREOTACTIC RADIOSURGERY SOCIETY PRACTICE OPINION
Kotecha R, Sahgal A, Rubens M, De Salles A, Fariselli L, Pollock BE, Levivier M, Ma L, Paddick I, Regis J, Sheehan J, Yomo S, Suh JH
Neuro Oncol. 2020 Mar 5;22(3):318-332
DOI: 10.1093/neuonc/noz225

STEREOTACTIC RADIOSURGERY FOR BENIGN (WORLD HEALTH ORGANIZATION GRADE I) CAVERNOUS SINUS MENINGIOMAS - INTERNATIONAL STEREOTACTIC RADIOSURGERY SOCIETY (ISRS) - PRACTICE GUIDELINE: A SYSTEMATIC REVIEW
Lee CC, Trifiletti DM, Sahgal A, DeSalles A, Fariselli L, Hayashi M, Levivier M, Ma L, Álvarez RM, Paddick I, Regis J, Ryu S, Slotman B, Sheehan J. 
Neurosurgery. 2018 Mar 15.
DOI: 10.1093/neuros/nyy009

STEREOTACTIC RADIOSURGERY FOR VESTIBULAR SCHWANNOMA: INTERNATIONAL STEREOTACTIC RADIOSURGERY SOCIETY (ISRS) PRACTICE GUIDELINE
Tsao M, Sahgal A, Xu W, De Salles A, Hayashi M, Levivier M, Ma L, Martinez R, Régis J, Ryu S, Slotman B, Paddick I
Journal of radiosurgery and SBRT. 2017 Vol. 5 (1), 5-24.


FUNCTIONAL/EPILEPSY

STEREOTACTIC RADIOSURGERY FOR TRIGEMINAL NEURALGIA
Tuleasca C, Régis J, Sahgal A, De Salles A, Hayashi M, Ma L, Martínez-Alvarez R, Paddick JI, Ryu S, Slotman BJ, Levivier M.
J Neurosurg. 2018 Apr 27:1-25.
DOI: 10.3171/2017.9.JNS17545

STEREOTACTIC RADIOSURGERY FOR TREMOR
Martínez-Moreno N, Sahgal A, De Salles A, Hayashi M, Levivier M, Ma L, Paddick I, Régis J, Ryu S, Slotman B, Martínez-Álvarez R
Journal of Neurosurgery 2018 23(2) 1-12.
DOI: 10.3171/2017.8.JNS17749

GAMMA KNIFE RADIOSURGERY FOR EPILEPSY
McGonigal A, Sahgal A, De Salles A, Hayashi M, Levivier M, Ma L, Martinez R, Paddick I, Ryu S, Slotman B, Régis J
Epilepsy research 2017 Vol 137 123-131.
DOI: 10.1016/j.eplepsyres.2017.08.016

 

MALIGNANT TUMORS

ACCEPTED PAPER

 

Stereotactic Radiosurgery for Postoperative Metastatic Surgical Cavities: A Critical Review and International Stereotactic Radiosurgery Society (ISRS) Practice Guidelines
Kristin J. Redmond, Antonio A.F. De Salles, Laura Fariselli, Marc Levivier, Lijun Ma, Ian Paddick, Bruce E. Pollock, Jean Regis, Jason Sheehan, John Suh, Shoji Yomo, Arjun Sahgal
International Journal of Radiation Oncology, Biology, Physics. In Press

[PDF]

DOI: https://doi.org/10.1016/j.ijrobp.2021.04.016


STEREOTACTIC RADIOSURGERY IN THE MANAGEMENT OF LIMITED BRAIN METASTASES (ONE TO FOUR)
Chao S, De Salles A, Hayashi M, Levivier M, Ma L, Martinez R, Paddick I, Régis J, Ryu S, Slotman B, Sahgal A
Neurosurgery 2017 11(3)
DOI: 10.1093/neuros/nyx522

In Development
Cavity SRS: Kristen Redmond and Arjun Sahgal
Multiple Brain Metastases (>5): Steve Braunstein and Lijun Ma
Technical guidelines for stereotactic radiosurgery: Treatment of small metastases (


VASCULAR DISORDERS

STEREOTACTIC RADIOSURGERY FOR SPETZLER-MARTIN GRADE I AND II ARTERIOVENOUS MALFORMATIONS: INTERNATIONAL SOCIETY OF STEREOTACTIC RADIOSURGERY (ISRS) PRACTICE GUIDELINE
Graffeo CS, Sahgal A, De Salles A, Fariselli L, Levivier M, Ma L, Paddick I, Regis JM, Sheehan J,Suh J, Yomo S, Pollock BE
Neurosurgery. 2020 Feb 17.
DOI: 10.1093/neuros/nyaa004